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                 March 4, 2021

       Dr. Ian Walters
       Chief Executive Officer and Director
       Portage Biotech Inc.
       6 Adelaide St. East, Suite 300
       Toronto, Ontario, Canada M5C 1H6

                                                        Re: Portage Biotech
Inc.
                                                            Registration
Statement on Form F-3
                                                            Filed February 24,
2021
                                                            File No. 333-253468

       Dear Dr. Walters:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

              Please contact Irene Barberena-Meissner, Staff Attorney, at
202-551-6548 with any
       questions.




                 Sincerely,


                 Division of Corporation Finance

                 Office of Energy & Transportation
       cc:                                              Andrew Hudders, Esq.